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As the founder and CEO of Exscientia plc, Andrew Hopkins has led the way in developing novel medications through the application of AI and machine learning.
Hopkins oversaw the teams that found the first medications to go through human clinical trials, which were created using a lot of machine learning and artificial intelligence generating techniques. Exscientia received the Prix Galien USA for Digital Health in 2022 and the Prix Galien UK in the same category for their end-to-end AI-driven precision medicine platform.
Today, Exscientia plc and Merck KGaA, Darmstadt, Germany, launched a new partnership centered on the search for innovative small molecule therapeutic candidates in the fields of immunology, neuroinflammation, and cancer. The multi-year partnership will make use of Merck KGaA, Darmstadt, Germany’s clinical development skills, worldwide reach, and disease knowledge in cancer and neuroinflammation, as well as Exscientia’s AI-driven precision medication design and discovery capabilities.
The partnership’s initial emphasis will be on three possible first-in-class or best-in-class objectives. Through their partnership, Merck KGaA, Darmstadt, Germany, and Exscientia are able to discover new targets in immunology, cancer, and other diseases that have been jointly agreed upon. Should Exscientia uncover other targets for the agreement, the firm would be responsible for target validation in addition to drug design and eligible for further discovery milestones.
According to the terms of the agreement, Exscientia will get $20 million from Merck KGaA, Darmstadt, Germany, as an upfront cash payment. If all milestones for the three initial programs are met, Exscientia will also be eligible for milestone payments of up to $674 million in the aggregate for development, sales, and regulatory work. Merck KGaA, Darmstadt, Germany will pay Exscientia tiered royalties on product sales ranging from mid-single-digits to low-double-digits if the company commercializes a therapy from one of the collaboration’s early objectives. The $20 million upfront cash payment is anticipated to be recognized as revenue during the course of the agreement and appear in Exscientia’s second-half 2023 results as cash inflows from collaborations.
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